Characterization of gastric mucosal membranes. VI. The presence of channel-forming substances

Academic Article


  • Highly purified gastric membranes were extracted by ionic or non-ionic detergents. Further fractionation was carried out on acrylamide gel electrophoresis. Some defined bands, incorporated into artificial bilayer membranes, produced discrete conductance changes characteristics of channel activity. A low molecular weight peak, purified through two cycles of electrophoresis was characterized as an anion-selective, positively voltage dependent channel, and a model to account for the action of the transport ATPase incoporating this channel concept is suggested. © 1974.
  • Digital Object Identifier (doi)

    Author List

  • Sachs G; Spenney JG; Saccomani G; Goodall MC
  • Start Page

  • 233
  • End Page

  • 247
  • Volume

  • 332
  • Issue

  • 2