African Ancestry Gradient Is Associated with Lower Systemic F2-Isoprostane Levels.

Academic Article

Abstract

  • Context. Low levels of systemic F2-isoprostanes (F2-IsoP) increase the risk of diabetes and weight gain and were found in African Americans. Low F2-IsoPs could reflect an unfavorable metabolic characteristic, namely, slow mitochondrial metabolism in individuals with African ancestry. Objective. To examine differences in plasma F2-IsoPs in three groups with a priori different proportion of African ancestry: non-Hispanic Whites (NHWs), US-born African Americans (AAs), and West African immigrants (WAI). Design. Cross-sectional study. Setting. Georgia residents recruited from church communities. Participants. 218 males and females 25-74 years of age, who are self-identified as NHW (n = 83), AA (n = 56), or WAI (n = 79). Main Outcome Measure(s). Plasma F2-IsoPs quantified by gas chromatography-mass spectrometry. Results. After adjustment for age, gender, obesity, and other comorbidities, WAI had lower levels of plasma F2-IsoP than AA (beta-coefficient = -9.8, p < 0.001) and AA had lower levels than NHW (beta-coefficient = -30.3, p < 0.001). Similarly, among healthy nonobese participants, F2-IsoP levels were lowest among WAI, followed by AA, and the highest levels were among NHW. Conclusion. Plasma F2-IsoPs are inversely associated with African ancestry gradient. Additional studies are required to test whether optimization of systemic F2-IsoP levels can serve as means to improve race-specific lifestyle and pharmacological intervention targeted to obesity prevention and treatment.
  • Keywords

  • Adult, Africa, Western, African Americans, African Continental Ancestry Group, Aged, Biomarkers, Cross-Sectional Studies, European Continental Ancestry Group, F2-Isoprostanes, Female, Humans, Male, Middle Aged, Obesity, Oxidative Stress
  • Digital Object Identifier (doi)

    Author List

  • Annor F; Goodman M; Thyagarajan B; Okosun I; Doumatey A; Gower BA; Il'yasova D
  • Start Page

  • 8319176
  • Volume

  • 2017