© 2014 by Nova Science Publishers, Inc. All rights reserved. Gastrointestinal (GI) bleeding is one of frequent emergencies that clinicians frequently manage in clinical practice. This book contains several chapters dedicated to the diagnosis and management of gastrointestinal bleeding. This book includes current updates on all areas of GI bleeding including upper GI, lower GI, and small bowel bleeding. It fully covers the different symptoms and signs of gastrointestinal bleeding that can occur in different conditions. The outline of the many dilemmas faced by clinicians in their approach to their patients like diagnostic predictors of clinical outcome, and risk stratification in lower GI bleeding and for upper GI bleeding. There is a dedicated chapter for the diagnosis and management of Dieulafoy lesions (DLs) which are uncommon, yet they are often an under-recognized cause of life-threatening GI bleeding occurring in both the adult and pediatric population. This book also gives a comprehensive overview of the various imaging modalities used for the diagnosis of GI bleeding with emphasis on the role of MDCT in the care of patients with GI hemorrhage. The initial management of significant GI bleeding with focuses on early identification, hemodynamic stabilization, close monitoring in the proper setting, and timely workup and intervention is described. A dedicated chapter discusses the wide range of endoscopic therapies that are now available to treat GI bleeding, with emphasis on the new advances in endoscopic therapy. There is detailed discussion on the role of transcatheter arterial embolization, which remains an important available treatment modality in the armamentarium for management of non-variceal GI bleeding. A review of the primary prevention of variceal hemorrhage, management of acute variceal hemorrhage, and secondary prevention of variceal hemorrhage is presented. A comprehensive discussion on the surgical and endovascular management of variceal bleeding using transjugular intrahepatic porto-systemic shunt (TIPS) as well as surgical shunts is included in this book. This book will be of great value to many clinicians in different specialties including general practitioners, general internal medicine, gastrointestinal medicine, interventional radiologists and gastrointestinal surgeons.