Regeneration of t cells after chemotherapy

Academic Article


  • To the Editor: Mackall et al. (Jan. 19 issue)1 clearly demonstrate an inverse relation between age and the ability to regenerate CD4+ populations of T lymphocytes after intensive chemotherapy. They suggest that involution of the thymus (which occurs naturally with age) is likely to account for the diminished capacity to produce CD4+ cells. In the light of what is now known about extrathymic T-cell differentiation, however, the conclusion that “rapid T-cell regeneration requires residual thymic function” cannot be made without first examining CD8+ cell populations, which may have differentiated without a thymic influence. Studies in mice have shown that T-lymphocyte. © 1995, Massachusetts Medical Society. All rights reserved.
  • Published In

    Digital Object Identifier (doi)

    Author List

  • Cunnane G; O'farrelly C; Michie CA; Mclean AR; Moreland LW; Bucy RP; Koopman WJ; Mackall CL; Steinberg SM; Gress RE
  • Start Page

  • 1650
  • End Page

  • 1652
  • Volume

  • 332
  • Issue

  • 24