TGF-β inhibition of fas initiated apoptosis: The role of c-myc

Academic Article

Abstract

  • TGF-β a pleiotropic, peptide growth factor has usually been associated with the initiation of apoptosis. We have shown in three human tumor cell lines, using acridine orange staining and fluorescent microscopy, that TGF-β can protect cells from, the onset of Fas initiated apoptosis. This protection is apparently not associated with growth inhibition or cell adhesion. We have investigated whether the down regulation of c-myc. a known activity of TGFβ, could be responsible for this protection.
  • Authors

    Published In

  • The FASEB Journal  Journal
  • Author List

  • Winokur TS; Jones D
  • Volume

  • 10
  • Issue

  • 6