Twin-to-twin transfusion syndrome: Part 1. Types and pathogenesis

Academic Article


  • Twin-to-twin transfusion syndrome (TTTS) may be acute of chronic, but chronic TTTS complicates 10% to 20% of monochorionic twin gestations and has an 80% to 100% mortality rate if severe and left intreated. Both types are due to the presence of placental anastromoses between the two twins, but the mechanisms involved in the development of chronic TTTS are particularly complex and incompletely understood. Many of the apparent pathogenic mechanisms have implications for the appearances and cardiovascular and physiologic disturbances of neonates born following this intrauterine condition and their response to treatment. We present an update in the pathogenesis of TTTS that includes an overview of the placental features, fetal adaptive and maladaptive responses, and molecular mechanisms involved in the development of TTTS.
  • Digital Object Identifier (doi)

    Pubmed Id

  • 24183452
  • Author List

  • Faye-Petersen OM; Crombleholme TM
  • Volume

  • 9
  • Issue

  • 9