Myokymia, neuromyotonia, dermatomyositis, and voltage-gated K+ channel antibodies.

Academic Article


  • A young woman presented with facial myokymia in association with dermatomyositis. There was no evidence of peripheral neuropathy. Needle electromyography showed prominent myokymic discharges and brief neuromyotonic discharges in addition to many small-amplitude, short-duration motor unit potentials. Myokymia and dermatomyositis both responded to immunosuppressive treatment. The presence of antibodies to voltage-gated potassium channels and the association with dermatomyositis indicated an autoimmune cause for myokymia, which may have been due to reversible peripheral nerve hyperexcitability.
  • Authors

    Published In

  • Muscle and Nerve  Journal
  • Keywords

  • Action Potentials, Adult, Autoantibodies, Cyclophosphamide, Dermatomyositis, Facial Nerve Diseases, Female, Humans, Immunoglobulins, Intravenous, Isaacs Syndrome, Methylprednisolone, Muscle, Skeletal, Phenytoin, Potassium Channels, Voltage-Gated, Prednisone, Recurrence
  • Digital Object Identifier (doi)

    Pubmed Id

  • 19012867
  • Author List

  • Oh SJ; Alapati A; Claussen GC; Vernino S
  • Start Page

  • 757
  • End Page

  • 760
  • Volume

  • 27
  • Issue

  • 6