Synthesis of 4'-thio-beta-D-arabinofuranosylcytosine (4'-thio-ara-C) and comparison of its anticancer activity with that of ara-C.

Academic Article

Abstract

  • 4'-thio-beta-D-arabinofuranosylcytosine was synthesized by a facile route in high yields. It was evaluated for antitumor activity against a panel of human tumors, both in vitro and in vivo.
  • Published In

    Keywords

  • Animals, Antimetabolites, Antineoplastic, Antineoplastic Agents, Arabinonucleosides, Cytarabine, DNA Replication, DNA, Neoplasm, Drug Screening Assays, Antitumor, Humans, Inhibitory Concentration 50, Mice, Mice, Nude, Phosphorylation, Tumor Cells, Cultured
  • Digital Object Identifier (doi)

    Authorlist

  • Tiwari KN; Shortnacy-Fowler AT; Cappellacci L; Parker WB; Waud WR; Montgomery JA; Secrist JA
  • Start Page

  • 329
  • End Page

  • 340
  • Volume

  • 19
  • Issue

  • 1-2