Isolation and characterization of a murine P388 leukemia line resistant to clofarabine.

Academic Article

Abstract

  • A murine P388 leukemia line fully resistant to clofarabine was obtained after only two courses of intraperitoneal treatment (three times a day for nine consecutive days). The resistance was stable for at least 13 weeks without treatment. The subline was as sensitive to 5-fluorouracil, methotrexate, cyclophosphamide, cisplatin, melphalan, BCNU, doxorubicin, etoposide, irinotecan, vincristine, and docetaxel as was the parental P388/0 line but was cross-resistant to five antimetabolites [palmO-ara-C, 4'-thio-ara-C, fludarabine phosphate, cladribine, and gemcitabine-all of which require deoxycytidine kinase for activation] and paclitaxel. The subline had less than 1% of the deoxycytidine kinase activity in comparison to P388/0.
  • Published In

    Keywords

  • Adenine Nucleotides, Animals, Antineoplastic Agents, Arabinonucleosides, Cell Line, Tumor, Cell Separation, Clofarabine, Deoxycytidine Kinase, Drug Resistance, Neoplasm, Leukemia P388, Mice
  • Digital Object Identifier (doi)

    Pubmed Id

  • 21565557
  • Author List

  • Waud WR; Gilbert KS; Parker WB; Secrist JA
  • Start Page

  • 826
  • End Page

  • 838
  • Volume

  • 30
  • Issue

  • 11