Donor-derived organ transplant transmission of coccidioidomycosis.

Academic Article

Abstract

  • Coccidioidomycosis in solid organ transplant recipients most often occurs as a result of primary infection or reactivation of latent infection. Herein, we report a series of cases of transplant-related transmission of coccidioidomycosis from a single donor from a non-endemic region whose organs were transplanted to 5 different recipients. In all, 3 of the 5 recipients developed evidence of Coccidioides infection, 2 of whom had disseminated disease. The degree of T-cell immunosuppression and timing of antifungal therapy initiation likely contributed to development of disease and disease severity in these recipients. This case series highlights the importance of having a high index of suspicion for Coccidioides infection in solid organ transplant recipients, even if the donor does not have known exposure, given the difficulties of obtaining a detailed and accurate travel history from next-of-kin.
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    Keywords

  • Adolescent, Antifungal Agents, Coccidioides, Coccidioidomycosis, Fatal Outcome, Female, Fluconazole, Fungemia, Humans, Immunosuppression, Male, Middle Aged, Organ Transplantation, T-Lymphocytes, Tissue Donors, Tissue and Organ Harvesting, Travel, Young Adult
  • Digital Object Identifier (doi)

    Author List

  • Dierberg KL; Marr KA; Subramanian A; Nace H; Desai N; Locke JE; Zhang S; Diaz J; Chamberlain C; Neofytos D
  • Start Page

  • 300
  • End Page

  • 304
  • Volume

  • 14
  • Issue

  • 3