Donor-derived organ transplant transmission of coccidioidomycosis

Academic Article

Abstract

  • Coccidioidomycosis in solid organ transplant recipients most often occurs as a result of primary infection or reactivation of latent infection. Herein, we report a series of cases of transplant-related transmission of coccidioidomycosis from a single donor from a non-endemic region whose organs were transplanted to 5 different recipients. In all, 3 of the 5 recipients developed evidence of Coccidioides infection, 2 of whom had disseminated disease. The degree of T-cell immunosuppression and timing of antifungal therapy initiation likely contributed to development of disease and disease severity in these recipients. This case series highlights the importance of having a high index of suspicion for Coccidioides infection in solid organ transplant recipients, even if the donor does not have known exposure, given the difficulties of obtaining a detailed and accurate travel history from next-of-kin. © 2011 John Wiley & Sons A/S.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Dierberg KL; Marr KA; Subramanian A; Nace H; Desai N; Locke JE; Zhang S; Diaz J; Chamberlain C; Neofytos D
  • Start Page

  • 300
  • End Page

  • 304
  • Volume

  • 14
  • Issue

  • 3