Murine pancreatic beta-cells express H-2K and H-2D but not Ia antigens.

Academic Article


  • Direct microcytotoxicity testing and absorption analyses were employed to determine whether H-2K, H-2D, and Ia antigens are present on murine islet of Langerhans cells. Products of the H-2K and H-2D loci were found on beta-cells from three different mouse strains, but I-region (Ia) antigens were not detected. The absence of Ia gene products from islet cells may be of importance in explaining the survival of islet allografts across major histocompatibility barriers.
  • Published In

    Digital Object Identifier (doi)

    Pubmed Id

  • 9369318
  • Author List

  • Faustman D; Hauptfeld V; Davie JM; Lacy PE; Shreffler DC
  • Start Page

  • 1563
  • End Page

  • 1568
  • Volume

  • 151
  • Issue

  • 6