Studies on recombination within the mouse H-2 complex: IV. Characterization of new recombinant haplotypes H-2t7, H-2t8, H-2as2, and H-2as3.

Academic Article

Abstract

  • Four new intra-H-2 recombinants were characterized serologically and functionally. In two of these recombinants, B10.ASR1 and B10.ASR7, crossing over occurred between the A alpha and E alpha subregions, very probably in E beta since most intra-I region recombinants thus far investigated at the DNA level appear to involve recombination within the E beta gene. In the other two recombinants, B10.ASR2 and B10.ARS8, crossing over occurred between the S and D subregions. B10.ASR2 and B10.ASR8, crossing over occurred between the S and D subregions. B10.ASR7, which is serologically indistinguishable from B10.BASR1 and B10.S(8R), slightly stimulates and strongly responds to both of these strains in MLR. The probable location of the B10.S(8R) stimulatory product is E beta. The H-2 composition of B10.ASR1 is closest to that of B10.S(9R) and B10.HTT; therefore, precise definition of the cross-over point at the DNA level will be of particular interest.

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    Keywords

  • Animals, Chromosome Mapping, Crossing Over, Genetic, H-2 Antigens, Haplotypes, Hemagglutination Tests, Histocompatibility Antigens Class II, Lymphocyte Culture Test, Mixed, Major Histocompatibility Complex, Mice, Mice, Inbred Strains, Povidone, Recombination, Genetic, Skin Transplantation

    • Author List

  • Hauptfeld M; Hauptfeld V; Zeff R; Shreffler DC

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  • 4

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