RS-61443 reverses acute renal allograft rejection in dogs.

Academic Article

Abstract

  • RS-61443 is a noncompetitive allosteric inhibitor of inosine monophosphate dehydrogenase. It blocks the proliferative response of T and B lymphocytes, prevents the generation of cytotoxic T cells, and inhibits antibody formation. This study was conducted to see whether or not RS-61443 can reverse acute renal allograft rejection in dogs. It was possible to reverse this process.
  • Pubmed Id

  • 10925145
  • Author List

  • Platz KP; Bechstein WO; Eckhoff DE; Hullett DA; Sollinger HW
  • Volume

  • 5 Suppl 1