RS-61443 reverses acute renal allograft rejection in dogs.

Academic Article


  • RS-61443 is a noncompetitive allosteric inhibitor of inosine monophosphate dehydrogenase. It blocks the proliferative response of T and B lymphocytes, prevents the generation of cytotoxic T cells, and inhibits antibody formation. This study was conducted to see whether or not RS-61443 can reverse acute renal allograft rejection in dogs. It was possible to reverse this process.
  • Published In


  • Acute Disease, Animals, Dogs, Female, Graft Rejection, Immunosuppressive Agents, Kidney Transplantation, Lymphocyte Activation, Models, Animal, Mycophenolic Acid, T-Lymphocytes, Time Factors, Transplantation, Homologous
  • Pubmed Id

  • 10925145
  • Author List

  • Platz KP; Bechstein WO; Eckhoff DE; Hullett DA; Sollinger HW
  • Start Page

  • S542
  • End Page

  • S543
  • Volume

  • 5 Suppl 1