Ischemia/reperfusion injury in microvascular surgery.

Academic Article


  • Ischemia/reperfusion injury is often the final and irreversible factor causing flap failure in microvascular surgery for head and neck defects. This paper begins with a detailed review of flap physiology and ischemia/reperfusion injury at the cellular level. Subsequently, the pharmacotherapeutic agents used clinically and experimentally to avoid or reverse ischemia/reperfusion injury are discussed. The goal of this review is to provide a framework for understanding the expanding body of literature relevant to ischemia/reperfusion injury in microvascular surgery.
  • Published In


  • Endothelium, Vascular, Free Radicals, Head, Humans, Inflammation Mediators, Microsurgery, Neck, Neutrophils, Reperfusion Injury, Surgical Flaps, Thromboplastin, Thrombosis, Vascular Surgical Procedures
  • Author List

  • Carroll WR; Esclamado RM
  • Start Page

  • 700
  • End Page

  • 713
  • Volume

  • 22
  • Issue

  • 7