Influence of prostaglandin D2 on hemodynamic effects of group B streptococcus in neonatal lambs.

Academic Article


  • Infusions of group B streptococci cause pulmonary hypertension in several neonatal animal models. A continuous infusion of prostaglandin D2 reduced the magnitude of this pulmonary hypertensive response; indomethacin completely blocked the response. Prostaglandin D2 or cyclooxygenase inhibitors may be important therapeutic agents for infants with group B streptococcal sepsis who manifest pulmonary hypertension.
  • Keywords

  • Animals, Animals, Newborn, Blood Pressure, Hemodynamics, Hypertension, Pulmonary, Indomethacin, Prostaglandin D2, Prostaglandins D, Pulmonary Circulation, Sheep, Streptococcal Infections, Streptococcus agalactiae, Vascular Resistance
  • Author List

  • Huddleston KW; Lyrene RK; Dew A; Gray BM; Philips JB
  • Start Page

  • 260
  • End Page

  • 265
  • Volume

  • 9
  • Issue

  • 4