Low colloid osmotic pressure in very low birthweight infants receiving assisted ventilation

Academic Article


  • Plasma colloid osmotic pressure (COP) was measured in three groups of very low birthweight infants. Babies in Group 1 (n= 8) were breathing spontaneously and had no respiratory disease. Those in Group 2 (n= 9) received assisted ventilation for hyaline membrane disease (HMD), and those in Group 3 (n= 7) received assisted ventilation for other reasons (five apnoea, two pneumonia). Both assisted ventilation groups had lower mean COP values than spontaneously breathing infants. Mean values (s.e.m.) for Groups 1,2 and 3, respectively, were: 15.3 (0.6), 11.3 (0.4) and 11.9 mmHg (0.5)(P < 0.001) on Day 1; and 15.2 (0.4), 12.9 (0.4) and 12.8 mmHg (0.3) (P < 0.001) on Day 2. The Increase from Day 1 to Day 2 was significant for those with HMD (P < 0.05). Colloid osmotic pressure correlated with mean blood pressure (r= 0.51; P< 0.001) but not with birthweight, gestation, crystalloid fluid intake or pH. The role of low COP in the pathogenesis of acute respiratory failure in infants with uncomplicated HMD is unclear, but such low COP may contribute to development of pulmonary oedema as a complication, particularly if the ductus'arteriosus is still patent and the infants are given high volume intravenous fluids. Copyright © 1987, Wiley Blackwell. All rights reserved
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  • Start Page

  • 189
  • End Page

  • 192
  • Volume

  • 23
  • Issue

  • 3