Treatment of patients with sarcoidosis was initiated with alternate day prednisone. Responses were generally favorable. Five patients had complete regression of disease, two had excellent responses, and three had only slight regression. Side effects of alternate day prednisone were minimal, with weight gain and slight facial rounding being the primary manifestations of toxicity. Thus, it is the opinion of the authors that the patient with uncomplicated sarcoidosis who requires therapy can be started directly on alternate day prednisone.