Regulatory mechanisms in cell-mediated immune responses: III. I-region control of suppressor cell interaction with responder cells in mixed lymphocyte reactions*

Academic Article


  • Active suppression of mixed lymphocyte reaction (MLR) response is mediated by a soluble factor released by alloantigen-activated murine suppressor cells. Genetic restrictions controlling suppressor factor interaction with MLR responder cells were elucidated in this study. Non-H-2 genetic background was irrelevant to effective interaction. Using congenic strains and strains with intra-H-2 recombinants the genetic locus controlling suppressor T-cell-responder cell interaction was mapped in the I-C or S regions of the H-2 complex. Similarly, recombinant strains were used to exclude the presence of another suppressor cell-responder cell interaction locus in K, I-A, and I-B regions. It thus appears that the I-C subregion of the H-2 complex controls suppressive cell interactions in this T-cell-mediated immune response. © 1976, Rockefeller University Press., All rights reserved.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Rich SS; Rich RR
  • Start Page

  • 672
  • End Page

  • 677
  • Volume

  • 143
  • Issue

  • 3