Regulatory mechanisms in cell-mediated immune responses: V. H-2 homology requirements for the production of a minor locus-induced suppressor factor*

Academic Article


  • Mixed leukocyte reaction suppressor factor is produced by spleen cells sensitized in vivo and restimulated in vitro across non-H-2 antigenic barriers. Cells capable of producing this factor appear in the spleens of minor locusimmunized animals later than in animals sensitized to major histocompatibility complex-encoded antigens. However, both H-2 and non-H-2-induced factors suppress proliferative responses to any alloantigen. Splenocytes from animals immunized with H-2-identical, minor locus-disparate cells produce suppressor factor in vitro only wlien restimulated with cells sharing both H-2 and non-H-2 antigens with the in vivo stimulators. © American Society for Clinical Pathology.
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    Digital Object Identifier (doi)

    Author List

  • Kastner DL; Rich RR; Chu L; Rich SS
  • Start Page

  • 1152
  • End Page

  • 1157
  • Volume

  • 146
  • Issue

  • 4