Comparative analysis of commercial assays for the detection and quantification of human immunodeficiency virus type 1 (HIV-1) RNA in plasma from patients infected with HIV-1 subtype C

Academic Article

Abstract

  • The commercial assays commonly used to quantify plasma human immunodeficiency virus type 1 (HIV-1) RNA in clinical settings were designed to assess HIV-1 subtype B. We compared the performance of 4 commercial assays (Amplicor versions 1.0 and 1.5 [Roche]; Quantiplex [Chiron]; and NASBA HIV-1 RNA QT [Organon Teknika]) in detecting and quantifying HIV-1 RNA in plasma from HIV-infected persons from Zambia, an area where HIV-1 subtype C is predominant. Each assay detected plasma HIV-1 RNA, but they do not all measure statistically similar quantities of plasma HIV-1 RNA. © 2002 Infectious Diseases Society of America.
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    Digital Object Identifier (doi)

    Author List

  • Hoesley CJ; Allen SA; Raper JL; Musonda R; Niu Y; Gao F; Squires KE; Aldrovandi GM
  • Start Page

  • 323
  • End Page

  • 325
  • Volume

  • 35
  • Issue

  • 3