'Idiopathic' eosinophilia with an Occult T-cell clone: prevalence and clinical course.

Academic Article


  • In a study of 99 consecutive patients with "idiopathic" eosinophilia, clonal T-cells were demonstrated in blood, bone marrow, or other tissue samples of 14 patients including 6 who had an overt T-cell malignancy. The remaining eight patients (approximately 8%) with an "Occult" T-cell clone had predominantly cutaneous disease and FIP1L1-PDGFRA was absent in all six evaluable patients. Two patients were effectively treated with low-dose oral cyclophosphamide or methotrexate whereas Gleevec treatment was ineffective in another two patients. Two patients (25%) transformed into cutaneous T-cell lymphoma after 3-8 years of eosinophilic prodrome.
  • Published In

  • Leukemia Research  Journal
  • Keywords

  • Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Benzamides, Clone Cells, Cyclophosphamide, Eosinophilia, Female, Humans, Imatinib Mesylate, Leukemia, Lymphoid, Lymphoma, T-Cell, Peripheral, Male, Methotrexate, Middle Aged, Oncogene Proteins, Fusion, Piperazines, Prevalence, Pyrimidines, Receptor, Platelet-Derived Growth Factor alpha, T-Lymphocytes, mRNA Cleavage and Polyadenylation Factors
  • Digital Object Identifier (doi)

    Author List

  • Vaklavas C; Tefferi A; Butterfield J; Ketterling R; Verstovsek S; Kantarjian H; Pardanani A
  • Start Page

  • 691
  • End Page

  • 694
  • Volume

  • 31
  • Issue

  • 5