Positron Emission Tomography Imaging of Hypoxia.

Academic Article


  • Hypoxia imaging has applications in functional recovery in ischemic events such as stroke and myocardial ischemia, but especially in tumors in which hypoxia can be predictive of treatment response and overall prognosis. Recently there has been development of imaging agents utilizing positron emission tomography for non-invasive imaging of hypoxia. Many of these PET agents have come to the forefront of hypoxia imaging. Halogenated PET nitroimidazole imaging agents labeled with (18)F (t(1/2) = 110 m) and (124)I (t(1/2) = 110 m) have been under investigation for the last 25 years, with radiometal agents ((64)Cu-ATSM) being developed more recently. This review focuses on these positron emission tomography imaging agents for hypoxia.
  • Published In

  • PET Clinics  Journal
  • Digital Object Identifier (doi)

    Author List

  • Lapi SE; Voller TF; Welch MJ
  • Start Page

  • 39
  • End Page

  • 47
  • Volume

  • 4
  • Issue

  • 1