Long-term evaluation of TiO2-based 68Ge/68Ga generators and optimized automation of [68Ga]DOTATOC radiosynthesis.

Academic Article


  • Interest in using (68)Ga is rapidly increasing for clinical PET applications due to its favorable imaging characteristics and increased accessibility. The focus of this study was to provide our long-term evaluations of the two TiO(2)-based (68)Ge/(68)Ga generators and develop an optimized automation strategy to synthesize [(68)Ga]DOTATOC by using HEPES as a buffer system. This data will be useful in standardizing the evaluation of (68)Ge/(68)Ga generators and automation strategies to comply with regulatory issues for clinical use.
  • Published In


  • Automation, Gallium Radioisotopes, Germanium, Octreotide, Titanium
  • Digital Object Identifier (doi)

    Author List

  • Lin M; Ranganathan D; Mori T; Hagooly A; Rossin R; Welch MJ; Lapi SE
  • Start Page

  • 2539
  • End Page

  • 2544
  • Volume

  • 70
  • Issue

  • 10