A historical perspective on the specific activity of radiopharmaceuticals: what have we learned in the 35years of the ISRC?

Academic Article


  • Specific Activity (SA), defined as the amount of radioactivity per unit mass of a compound is arguably one of the most important parameters in radiopharmaceutical development, particularly in quality control of carbon-11 and fluorine-18 labeled compounds. This review article will outline the progression of improvements in SA over the last few decades. The International Symposium of Radiopharmaceutical Chemistry (ISRC/ISRS) abstracts were an excellent source of materials for this review and will be referenced throughout.
  • Published In


  • Congresses as Topic, Contrast Media, Databases, Pharmaceutical, History, 20th Century, History, 21st Century, Molecular Imaging, Radiochemistry, Radiopharmaceuticals
  • Digital Object Identifier (doi)

    Author List

  • Lapi SE; Welch MJ
  • Start Page

  • 314
  • End Page

  • 320
  • Volume

  • 40
  • Issue

  • 3