Cyclotron Production of (99m)Tc using (100)Mo2C targets.

Academic Article


  • An investigative study of the (100)Mo (p,2n)(99m)Tc reaction on a medical cyclotron using (100)Mo2C is reported. This is the first report of this compound being used as a target for this reaction. (100)Mo2C, a refractory carbide with high thermal conductivity, properties which underscore its use on a cyclotron, was synthesized using (100)MoO3. Its ease of oxidation back to (100)MoO3 under air at elevated temperatures facilitates the use of thermo-chromatography, a high temperature gas phase separation technique for the separation and isolation of (99m)Tc. Activity yields for (99m)Tc averaged 84% of the calculated theoretical yields. Additionally, the percent recovery of MoO3, the precursor for Mo2C, was consistently high at 85% ensuring a good life cycle for this target material. The produced (99m)Tc was radio-chemically pure and easily labeled MDP for imaging purposes.
  • Published In


  • (99m)Tc, Cyclotron, Mo(2)C, Thermochromatography, Animals, Cyclotrons, Isotopes, Mice, Molybdenum, Radiochemistry, Technetium, Technetium Tc 99m Medronate, Tomography, Emission-Computed, Single-Photon
  • Digital Object Identifier (doi)

    Author List

  • Richards VN; Mebrahtu E; Lapi SE
  • Start Page

  • 939
  • End Page

  • 945
  • Volume

  • 40
  • Issue

  • 7