Modification of D-galactosamine-induced liver injury in the rat by spironolactone.

Academic Article


  • Spironolactone, a competitive inhibitor of mineralocorticoid effects on the distal tubule of the kidney, has recently been found to have other metabolic effects. In these studies, spironolactone (200mg/kg intraperitoneally) for 3 days was found to have a marked protective effect against the hepatotoxic effect of D-galactosamine (275 mg/kg) in rats. Further progress in defining the mechanism of protection from D-galactosamine hepatic necrosis by spironolactone will require assessment of effects of spironolactone on uridine nucleotide metabolism.
  • Published In

  • Pharmacology  Journal
  • Keywords

  • Animals, Aspartate Aminotransferases, Bile Acids and Salts, Galactosamine, Injections, Intraperitoneal, Liver, Male, Necrosis, Rats, Spironolactone
  • Digital Object Identifier (doi)

    Author List

  • Mihas AA; Foster MM; Barnes S; Mihas TA; Hirschowitz BI; Spenney JG
  • Start Page

  • 235
  • End Page

  • 240
  • Volume

  • 18
  • Issue

  • 5