Modification of d-galactosamine-induced liver injury in the rat by spironolactone

Academic Article


  • Spironolactone, a competitive inhibitor of mineralocorticoid effects on the distal tubule of the kidney, has recently been found to have other metabolic effects. In these studies, spironolactone (200 mg/kg intraperitoneally) for 3 days was found to have a marked protective effect against die hepatotoxic effect of D-galactosamine (275 mg/kg) in rats. Further progress in defining the mechanism of protection from D-galactosamine hepatic necrosis by spironolactone will require assessment of effects of spironolactone on uridine nucleotide metabolism. © 1979 S. Karger AG, Basel.
  • Authors

    Published In

  • Pharmacology  Journal
  • Digital Object Identifier (doi)

    Author List

  • Mihas AA; Foster MM; Barnes S; Mihas TA; Hirschowitz BI; Spenney JG
  • Start Page

  • 235
  • End Page

  • 240
  • Volume

  • 18
  • Issue

  • 5