During the past decade, coronary artery disease has been recognized as one of the major health issues in the adult population, and as a result, intense interest was devoted to the investigation and management of patients with acute myocardial infarction. Major developments in noninvasive and invasive technologies to monitor the electrical and mechanical disturbances of the heart have been achieved.1-3 As the result of these investigations and techniques, the patient with acute infarction can be characterized by physiologic measurements of rhythm and mechanical function in the absence as well as in the presence of heart failure and cardiogenic shock. With such objective information available on cardiac performance in the individual patient, a variety of therapeutic strategies has become available.4-6 Thus management of acute myocardial infarction can range from home care or early hospital discharge to intervention with agents to salvage ischemic myocardium and reduce infarction size. This review will describe physiologic measurements in patients with acute myocardial infarction and will include information during the acute phase and several weeks after convalescence. The therapeutic options available in the acute and early convalescent phase will also be discussed. © 1981.