Susceptibility of nontypeable Haemophilus influenzae to human β-defensins is influenced by lipooligosaccharide acylation

Academic Article

Abstract

  • Nontypeable Haemophilus influenzae (NTHI) lipooligosaccharide htrB mutants exhibited greater than 45-fold-increased sensitivity to human β-defensin 2 (HBD-2) compared to the wild type. Complementation by htrB in trans to acylation competence reversed this increased sensitivity. In contrast, NTHI was more susceptible to HBD-3 and showed no changes in sensitivity as a result of lipooligosaccharide mutations in oligosaccharide and lipid A biosynthesis genes.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Starner TD; Swords WE; Apicella MA; McCray PB
  • Start Page

  • 5287
  • End Page

  • 5289
  • Volume

  • 70
  • Issue

  • 9