Effects of antihypertensive drugs on arterial stiffness.

Academic Article


  • In this review, we discuss the possible pathophysiological mechanisms and the role of arterial stiffness as a biomarker, a blood pressure-independent predictor of cardiovascular morbidity and mortality. The effects of different antihypertensive drug classes on noninvasively assessed markers of arterial stiffness are also discussed. Current evidence will be reviewed regarding the effect of drugs on arterial stiffness, including the peripheral and central effects of angiotensin-converting enzyme inhibitors, angiotensin receptor antagonists, dihydropyridine calcium channel blockers, beta blockers (including vasodilating beta blockers), diuretics, and mineralocorticoid antagonists.
  • Published In


  • Adrenergic beta-Agonists, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Antihypertensive Agents, Calcium Channel Blockers, Diuretics, Humans, Hypertension, Meta-Analysis as Topic, Mineralocorticoid Receptor Antagonists, Randomized Controlled Trials as Topic, Renin, Vascular Stiffness
  • Digital Object Identifier (doi)

    Pubmed Id

  • 21724716
  • Author List

  • Dudenbostel T; Glasser SP
  • Start Page

  • 259
  • End Page

  • 263
  • Volume

  • 20
  • Issue

  • 5