Delayed foreign-body reaction to silk sutures in pediatric neurosurgical patients.

Academic Article


  • Nonabsorbable silk sutures have been a frequently used foreign material in neurosurgery. In general, they are reliable and safe with minimal bio-incompatibility. Three pediatric neurosurgical patients came to clinical attention, however, because of delayed foreign-body reactions to silk sutures. The delayed atypical presentation of these patients delayed appropriate diagnosis and therapy. In two patients, the reaction presented as a delayed inflammation 7 years following surgical suture placement. In the other patient, the reaction caused delayed recurrent shunt failures and surgical wound breakdown. These three cases are used to introduce a discussion of the delayed response of the host to foreign material and its pertinence to neurosurgery.
  • Authors

    Published In


  • Adolescent, Adult, Brain, Child, Female, Foreign-Body Reaction, Humans, Insect Proteins, Proteins, Reoperation, Silk, Sutures, Time Factors
  • Author List

  • Rossitch E; Bullard DE; Oakes WJ
  • Start Page

  • 375
  • End Page

  • 378
  • Volume

  • 3
  • Issue

  • 6