Transient late magnetic resonance imaging changes suggesting progression of brain stem glioma: implications for entry criteria for phase II trials.

Academic Article


  • An 8-year-old boy was treated with irradiation (66 Gy) for a brain stem glioma. Five months after the completion of radiotherapy, magnetic resonance imaging demonstrated apparent tumor progression despite the patient's neurological improvement. The child continued to improve, with subsequent radiographic evidence of tumor regression, without additional therapeutic intervention. The evaluations of response and recurrence of brain tumors as well as entry criteria for Phase II studies are discussed.
  • Authors

    Published In

  • Neurosurgery  Journal
  • Keywords

  • Antineoplastic Agents, Brain Neoplasms, Brain Stem, Child, Clinical Trials as Topic, Glioma, Humans, Magnetic Resonance Imaging, Male, Neurologic Examination, Tomography, X-Ray Computed
  • Author List

  • Longee DC; Friedman HS; Djang WT; Halperin E; Schold SC; Oakes WJ
  • Start Page

  • 248
  • End Page

  • 253
  • Volume

  • 23
  • Issue

  • 2