Successful therapy for trilateral retinoblastoma

Academic Article

Abstract

  • Trilateral retinoblastoma, the intracranial malignancy associated with bilateral retinoblastoma, is an uncommon and clinically aggressive malignancy with a uniformly fatal outcome. Three children with newly diagnosed trilateral retinoblastoma were treated with systemic (cyclophosphamide and vincristine) and intrathecal (methotrexate, hydrocortisone, and cytarabine) chemotherapy, as well as craniospinal irradiation (one patient) in addition to therapy of the eye lesions. All three patients have had partial or complete response of the pineal tumors to chemotherapy, with no active disease eight or more years, 33 or more months, and 12 or more months, respectively, after diagnosis of the lesions.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Nelson SC; Friedman HS; Oakes WJ; Halperin EC; Tien R; Fuller GN; Hockenberger B; Scroggs MW; Moncino M; Kurtzberg J
  • Start Page

  • 23
  • End Page

  • 29
  • Volume

  • 114
  • Issue

  • 1