Comparison of serial PET and MRI scans in a pediatric patient with a brainstem glioma

Academic Article


  • Profound clinical deficits may be associated with insults to the brainstem, making management of patients with brainstem gliomas very complex. Small changes in the radiographic appearance of a brainstem tumor may be associated with significant clinical deterioration. Furthermore, both magnetic resonance imaging and computed tomography are frequently unable to differentiate between therapy‐related tissue reactions and progressive tumor. Two clinical scenarios particularly difficult to resolve include: (1) transient radiographic and clinical deterioration following hyperfractionated radiotherapy, and (2) clinical deterioration in a patient who has failed initial therapy, but has stable radiographic findings following a second therapy. We report a child with a pontine glioma whose tumor progression was demonstrated more convincingly with a 18F‐deoxyglucose positron emission scan than with magnetic resonance imaging. PET scans may be helpful in confirming that tumor progression is responsible for clinical deterioration in a patient whose MRI scans remain stable. © 1993 Wiley‐Liss, Inc. Copyright © 1993 Wiley‐Liss, Inc., A Wiley Company
  • Authors

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    Digital Object Identifier (doi)

    Author List

  • Bruggers CS; Friedman HS; Fuller GN; Tien RD; Marks LB; Halperin EC; Hockenberger B; Oakes WJ; Hoffman JM
  • Start Page

  • 301
  • End Page

  • 306
  • Volume

  • 21
  • Issue

  • 4