Comparison of serial PET and MRI scans in a pediatric patient with a brainstem glioma.

Academic Article


  • Profound clinical deficits may be associated with insults to the brainstem, making management of patients with brainstem gliomas very complex. Small changes in the radiographic appearance of a brainstem tumor may be associated with significant clinical deterioration. Furthermore, both magnetic resonance imaging and computed tomography are frequently unable to differentiate between therapy-related tissue reactions and progressive tumor. Two clinical scenarios particularly difficult to resolve include: (1) transient radiographic and clinical deterioration following hyperfractionated radiotherapy, and (2) clinical deterioration in a patient who has failed initial therapy, but has stable radiographic findings following a second therapy. We report a child with a pontine glioma whose tumor progression was demonstrated more convincingly with a 18F-deoxyglucose positron emission scan than with magnetic resonance imaging. PET scans may be helpful in confirming that tumor progression is responsible for clinical deterioration in a patient whose MRI scans remain stable.
  • Authors

    Published In


  • Brain Neoplasms, Brain Stem, Child, Cyclophosphamide, Dexamethasone, Female, Glioma, Granulocyte-Macrophage Colony-Stimulating Factor, Humans, Magnetic Resonance Imaging, Radiography, Tomography, Emission-Computed
  • Author List

  • Bruggers CS; Friedman HS; Fuller GN; Tien RD; Marks LB; Halperin EC; Hockenberger B; Oakes WJ; Hoffman JM
  • Start Page

  • 301
  • End Page

  • 306
  • Volume

  • 21
  • Issue

  • 4