Chiari I malformation and idiopathic growth hormone deficiency in siblings: report of three cases.

Academic Article


  • INTRODUCTION: The authors report a case of three brothers. CASE DESCRIPTIONS: Two of these siblings presented with congenital growth hormone deficiency (GHD) and Chiari I malformation (CIM). The third younger brother has been found not to have GHD or the CIM. DISCUSSION: Sparse cases of these two clinical occurrences have been reported. Further, the posterior cranial fossa (PF) has been determined to be altered in patients with CIM and GHD. CONCLUSION: Our current case reports strengthen the association between these two pathological entities and, to our knowledge, is the first description of both defects in siblings.
  • Authors

    Published In


  • Arnold-Chiari Malformation, Child, Child, Preschool, Encephalocele, Growth Hormone, Human Growth Hormone, Humans, Magnetic Resonance Imaging, Male, Rhombencephalon, Scoliosis, Syringomyelia
  • Digital Object Identifier (doi)

    Author List

  • Murphy RL; Tubbs RS; Grabb PA; Oakes WJ
  • Start Page

  • 1221
  • End Page

  • 1223
  • Volume

  • 23
  • Issue

  • 10