Histological study of the occipital bone from patients with Chiari I malformation

Academic Article

Abstract

  • © 2015, Springer-Verlag Berlin Heidelberg. Background: This study is focused on the histologic characteristics of occipital bone removed during Chiari I decompression in the hope of discovering unique features that may be related to the pathogenesis of this condition. Methods: Ten consecutive pediatric patients with Chiari I malformation underwent standard posterior fossa decompression surgery. Bone that was removed from the posterior fossa was sent for histological examination. Bone from age-matched controls also underwent histological analysis. Results: For all study and control specimens, bony samples were found to be made up of dense lamellar bone without marrow elements. In all aspects, histologically, the bone tissue had a normal appearance compared to control samples. Conclusions: Although many authors have mentioned that the occipital bone in patients with Chiari I malformation is abnormal on imaging or at operation (e.g., thinned, thickened), based on our study, there is no histological difference between the occipital bone removed at operation and controls.
  • Authors

    Digital Object Identifier (doi)

    Author List

  • Tubbs RS; Benzie AL; Rizk E; Chern JJ; Loukas M; Oakes WJ
  • Start Page

  • 351
  • End Page

  • 353
  • Volume

  • 32
  • Issue

  • 2