Neurodegeneration with Brain Iron Accumulation: Clinicoradiological Approach to Diagnosis

Academic Article


  • Discovery of genetic abnormalities associated with neurodegeneration with brain iron accumulation (NBIA) has led to use of a genetic-based NBIA classification schema. Most NBIA subtypes demonstrate characteristic imaging abnormalities. While clinical diagnosis of NBIA is difficult, analysis of both clinical findings and characteristic imaging abnormalities allows accurate diagnosis of most of the NBIA subtypes. This article reviews recent updates in the genetic, clinical, and imaging findings of NBIA subtypes and provides a practical step-by-step clinicoradiological algorithm toward clinical diagnosis of different NBIA subtypes.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Amaral LLF; Gaddikeri S; Chapman PR; Roy R; Gaddikeri RS; Marussi VH; Bag AK
  • Start Page

  • 539
  • End Page

  • 551
  • Volume

  • 25
  • Issue

  • 4