Interaction of modeling and experimental approaches to understanding renal salt and water balance

Academic Article


  • An overview is given on the challenges and opportunities that currently present themselves for integrating experimental and modeling approaches to kidney function and to whole body salt and water balance. Three examples of interfaces between renal physiology and modeling are presented. These examples include the current state of knowledge about the operation of the renal concentrating mechanism, osmotic volume absorption by the proximal tubule, and the role of abnormal regulation of salt absorption by the collecting duct in the production of hypertension.
  • Authors

    Published In

    Digital Object Identifier (doi)

    Author List

  • Schafer JA
  • Start Page

  • 1002
  • End Page

  • 1009
  • Volume

  • 28
  • Issue

  • 8