Blood stream infection is associated with altered heptavalent pneumococcal conjugate vaccine immune responses in very low birth weight infants.

Academic Article


  • OBJECTIVE: Sepsis in older children and adults modifies immune system function. We compared serotype-specific antibody responses to heptavalent pneumococcal conjugate vaccine (PCV7) in very low birth weight infants (<1500 g,VLBWs) with and without blood stream infection (BSI) during their birth hospitalization. STUDY DESIGN: Retrospective analysis of prospectively collected data for the Neonatal Research Network study of PCV7 responses among VLBWs. Infants received PCV7 at 2, 4 and 6 months after birth with blood drawn 4 to 6 weeks after third dose. Serotype antibodies were compared between infants with or without a history of BSI. Regression models were constructed with BW groups and other confounding factors identified in the primary study. RESULT: In all, 244 infants completed the vaccine series and had serum antibody available; 82 had BSI. After adjustment, BSI was not associated with reduced odds of serum antibody 0.35 μg ml(-1). CONCLUSION: BSI was not associated with reduced odds of World Health Organization-defined protective PCV7 responses in VLBWs.
  • Authors

    Published In


  • Female, Heptavalent Pneumococcal Conjugate Vaccine, Humans, Infant, Newborn, Infant, Premature, Diseases, Infant, Very Low Birth Weight, Male, Pneumococcal Vaccines, Retrospective Studies, Sepsis
  • Digital Object Identifier (doi)

    Author List

  • Wynn JL; Li L; Cotten CM; Phelps DL; Shankaran S; Goldberg RN; Carlo WA; Van Meurs K; Das A; Vohr BR
  • Start Page

  • 613
  • End Page

  • 618
  • Volume

  • 33
  • Issue

  • 8