Luminal and cellular mechanisms for the mediation of tubuloglomerular feedback responses

Academic Article


  • The results of our studies indicate that feedback-mediated changes in SFP are most likely the results of receptor cell detection of luminal fluid solute concentration. No specificity for any particular ion in mediating feedback responses could be identified. The detection of luminal fluid solute concentration may involve an intracellular cytoplamsic calcium system. The existence of a receptor cell intracellular calcium messenger system could serve as the link between changes in distal tubular fluid concentration and the alteration in glomerular vascular resistance.
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  • Bell PD
  • Volume

  • 22
  • Issue

  • Suppl. 12