Evidence for pericyte origin of TSC-associated renal angiomyolipomas and implications for angiotensin receptor inhibition therapy.

Academic Article

Abstract

  • Nearly all patients with tuberous sclerosis complex (TSC) develop renal angiomyolipomas, although the tumor cell of origin is unknown. We observed decreased renal angiomyolipoma development in patients with TSC2- polycystic kidney disease 1 deletion syndrome and hypertension that were treated from an early age with angiotensin-converting enzyme inhibitors or angiotensin receptor blockers compared with patients who did not receive this therapy. TSC-associated renal angiomyolipomas expressed ANG II type 1 receptors, platelet-derived growth factor receptor-β, desmin, α-smooth muscle actin, and VEGF receptor 2 but did not express the adipocyte marker S100 or the endothelial marker CD31. Sera of TSC patients exhibited increased vascular mural cell-secreted peptides, such as VEGF-A, VEGF-D, soluble VEGF receptor 2, and collagen type IV. These findings suggest that angiomyolipomas may arise from renal pericytes. ANG II treatment of angiomyolipoma cells in vitro resulted in an exaggerated intracellular Ca(2+) response and increased proliferation, which were blocked by the ANG II type 2 receptor antagonist valsartan. Blockade of ANG II signaling may have preventative therapeutic potential for angiomyolipomas.
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    Keywords

  • angiomyolipoma, angiotensin II type 1 receptor, mammalian target of rapamycin, pericyte, perivascular epithelioid cell tumor, tuberous sclerosis complex, Angiomyolipoma, Angiotensin II, Angiotensin Receptor Antagonists, Angiotensin-Converting Enzyme Inhibitors, Calcium, Cell Line, Tumor, Cell Proliferation, Humans, In Vitro Techniques, Kidney, Kidney Neoplasms, Pericytes, Receptor, Angiotensin, Type 1, Renin-Angiotensin System, Signal Transduction, Tetrazoles, Tuberous Sclerosis, Valine, Valsartan
  • Digital Object Identifier (doi)

    Author List

  • Siroky BJ; Yin H; Dixon BP; Reichert RJ; Hellmann AR; Ramkumar T; Tsuchihashi Z; Bunni M; Dillon J; Bell PD
  • Start Page

  • F560
  • End Page

  • F570
  • Volume

  • 307
  • Issue

  • 5