Molecular pathways and therapies in autosomal-dominant polycystic kidney disease.

Academic Article


  • Autosomal-dominant polycystic kidney disease (ADPKD) is the most prevalent inherited renal disease, characterized by multiple cysts that can eventually lead to kidney failure. Studies investigating the role of primary cilia and polycystins have significantly advanced our understanding of the pathogenesis of PKD. This review will present clinical and basic aspects of ADPKD, review current concepts of PKD pathogenesis, evaluate potential therapeutic targets, and highlight challenges for future clinical studies.
  • Published In


  • Animals, Cilia, Genetic Predisposition to Disease, Genetic Testing, Humans, Kidney, Molecular Targeted Therapy, Mutation, Phenotype, Polycystic Kidney, Autosomal Dominant, Predictive Value of Tests, Risk Factors, Signal Transduction, TRPP Cation Channels, Treatment Outcome
  • Digital Object Identifier (doi)

    Author List

  • Saigusa T; Bell PD
  • Start Page

  • 195
  • End Page

  • 207
  • Volume

  • 30
  • Issue

  • 3