Rapid, saturable, specific and stereoselective binding of L-dopa to crude membranes and membranes and purified nuclei from rodent amelanotic melanoma cells is reported. Cross-linking of [3H]dopa to melanoma cell surface emphasized proteins of approx. 55, 30, 25 and <20 kDA. It is suggestes that these binding sites may regulate melanocyte activity. © 1992.