Palmerolide A, a cytotoxic macrolide from the antarctic tunicate Synoicum adareanum

Academic Article

Abstract

  • Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 μM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase. Copyright © 2006 American Chemical Society.
  • Digital Object Identifier (doi)

    Author List

  • Diyabalanage T; Amsler CD; McClintock JB; Baker BJ
  • Start Page

  • 5630
  • End Page

  • 5631
  • Volume

  • 128
  • Issue

  • 17