Antimicrobial activities of gatifloxacin against nosocomial isolates of Stenotrophomonas maltophilia measured by MIC and time-kill studies.

Academic Article

Abstract

  • We determined in vitro activities of gatifloxacin and seven other drugs against 100 isolates of Stenotrophomonas maltophilia using the agar gradient diffusion (Etest) method. Percentages of susceptible isolates were as follows: trimethoprim-sulfamethoxazole, 90%; gatifloxacin, 71%; levofloxacin, 57%; ticarcillin-clavulanic acid, 54%; ceftazidime, 49%; ciprofloxacin, 29%; cefepime, 21%; and piperacillin-tazobactam, 20%. Time-kill studies of three isolates indicated that gatifloxacin was bactericidal at times as early as 3 h of incubation when tested at concentrations equivalent to twice the MIC (two isolates) and 4 times the MIC (one isolate).
  • Authors

    Published In

    Keywords

  • Anti-Infective Agents, Cross Infection, Fluoroquinolones, Gatifloxacin, Gram-Negative Bacterial Infections, Humans, Microbial Sensitivity Tests, Stenotrophomonas maltophilia, Time Factors
  • Digital Object Identifier (doi)

    Author List

  • Cohn ML; Waites KB
  • Start Page

  • 2126
  • End Page

  • 2128
  • Volume

  • 45
  • Issue

  • 7