Mutations in ribosomal proteins and ribosomal RNA confer macrolide resistance in human Ureaplasma spp.

Academic Article

Abstract

  • Genetic mechanisms of macrolide resistance were investigated in six isolates of Ureaplasma spp. with erythromycin minimum inhibitory concentrations (MICs)≥ 8 μg/mL that were derived from 370 cultures obtained over a several year period. Point mutations in domain V of 23S rRNA and/or mutations in ribosomal protein L4 genes are likely to be responsible for this drug resistance. Overall, macrolide resistance was uncommon, in contrast to tetracycline resistance that was documented in 121 unique isolates (33%).
  • Authors

    Keywords

  • Anti-Bacterial Agents, Drug Resistance, Microbial, Humans, Macrolides, Point Mutation, RNA, Ribosomal, Ribosomal Proteins, Ureaplasma
  • Digital Object Identifier (doi)

    Author List

  • Xiao L; Crabb DM; Duffy LB; Paralanov V; Glass JI; Hamilos DL; Waites KB
  • Start Page

  • 377
  • End Page

  • 379
  • Volume

  • 37
  • Issue

  • 4