Chromosomal mutations responsible for fluoroquinolone resistance in Ureaplasma species in the United States.

Academic Article

Abstract

  • We sequenced the full lengths of the gyrA, gyrB, parC, and parE genes in 13 fluoroquinolone-resistant Ureaplasma isolates (levofloxacin MICs, 4 to 32 μg/ml) and 10 susceptible isolates (MICs ≤ 2 μg/ml). Mutations were detected in all resistant isolates but in none of the susceptible isolates. The most prevalent mutation was the S83L substitution in the ParC protein. No plasmid-mediated fluoroquinolone resistance genes were detected.
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    Published In

    Keywords

  • Anti-Bacterial Agents, Chromosomes, Bacterial, DNA Gyrase, DNA Topoisomerase IV, Drug Resistance, Bacterial, Humans, Isoenzymes, Levofloxacin, Longitudinal Studies, Microbial Sensitivity Tests, Mutation, Ofloxacin, Sequence Analysis, DNA, United States, Ureaplasma, Ureaplasma Infections
  • Digital Object Identifier (doi)

    Author List

  • Xiao L; Crabb DM; Duffy LB; Paralanov V; Glass JI; Waites KB
  • Start Page

  • 2780
  • End Page

  • 2783
  • Volume

  • 56
  • Issue

  • 5