In vitro antibacterial activity of AZD0914 against human Mycoplasmas and Ureaplasmas.

Academic Article

Abstract

  • In this study, susceptibilities were determined for AZD0914, a spiropyrimidinetrione DNA gyrase inhibitor, azithromycin, doxycycline, and levofloxacin against Mycoplasma and Ureaplasma species. The activity of AZD0914 was comparable to that of levofloxacin and doxycycline against Mycoplasma genitalium and Mycoplasma pneumoniae. The AZD0914 MIC90 against Mycoplasma hominis was 8-fold greater than that for levofloxacin. The AZD0914 MIC90 against Ureaplasma species was 4-fold less than that for azithromycin and 8-fold less than that for levofloxacin and doxycycline.
  • Authors

    Published In

    Keywords

  • Anti-Bacterial Agents, Azithromycin, Barbiturates, Doxycycline, Humans, Levofloxacin, Microbial Sensitivity Tests, Mycoplasma, Mycoplasma genitalium, Mycoplasma pneumoniae, Spiro Compounds, Ureaplasma
  • Digital Object Identifier (doi)

    Author List

  • Waites KB; Crabb DM; Duffy LB; Huband MD
  • Start Page

  • 3627
  • End Page

  • 3629
  • Volume

  • 59
  • Issue

  • 6