In Vitro Activities of Omadacycline (PTK 0796) and Other Antimicrobial Agents against Human Mycoplasmas and Ureaplasmas.

Academic Article

Abstract

  • In vitro activities of omadacycline, a new aminomethylcycline, were determined for Mycoplasma and Ureaplasma spp. and compared with those of azithromycin, clindamycin, moxifloxacin, tetracycline, and doxycycline. All omadacycline MICs were <2 μg/ml. MIC90s were 0.063 μg/ml for Mycoplasma hominis, 0.25 μg/ml for Mycoplasma pneumoniae, and 2 μg/ml for Ureaplasma spp. Omadacycline had the lowest MIC90 among all drugs tested against M. hominis Omadacycline activity was not affected by macrolide, tetracycline, or fluoroquinolone resistance.
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    Published In

    Keywords

  • Anti-Bacterial Agents, Azithromycin, China, Clindamycin, Doxycycline, Drug Resistance, Multiple, Bacterial, Fluoroquinolones, Humans, Microbial Sensitivity Tests, Moxifloxacin, Mycoplasma Infections, Mycoplasma hominis, Mycoplasma pneumoniae, Tetracycline, Tetracyclines, United States
  • Digital Object Identifier (doi)

    Author List

  • Waites KB; Crabb DM; Liu Y; Duffy LB
  • Start Page

  • 7502
  • End Page

  • 7504
  • Volume

  • 60
  • Issue

  • 12