Fatty acids and breast cancer cell proliferation.

Academic Article


  • We and others have shown that fatty acids are important regulators of breast cancer cell proliferation. In particular individual fatty acids specifically alter EGF-induced cell proliferation in very different ways. This regulation is mediated by an EGFR/G-protein signaling pathway. Understanding the molecular mechanisms of how this signaling pathway functions and how fatty acids regulate it will provide important information on the cellular and molecular basis for the association of dietary fat and cancer. Furthermore these in vitro studies may explain data previously obtained from in vivo animal studies and identify "good" as well as "bad" fatty acids with respect to the development of cancer.
  • Keywords

  • Animals, Breast Neoplasms, Cell Division, Dietary Fats, Epidermal Growth Factor, Fatty Acids, Female, Forecasting, Humans
  • Author List

  • Hardy RW; Wickramasinghe NS; Ke SC; Wells A
  • Start Page

  • 57
  • End Page

  • 69
  • Volume

  • 422