T cell differentiation in birds

Academic Article


  • Avian T cell development has been traced using monoclonal antibodies specific for chicken T cell surface differentiation antigens. The basic antigen recognition molecules, differentiation pathways, and functional capabilities defined for T cells in mammals are highly conserved in birds. Novel features of T cell development are also revealed. These include the generation of a third T cell sublineage that expresses a different receptor isotype (TCR3) and a novel lineage of cytoplasmic CD3+ lymphoid cells (TCR0 cells). In contrast to the TCR0 cell lineage, the sublines of T cells bearing the three TCR isotypes are all generated exclusively within the thymus. © 1990 by W.B. Saunders Company.
  • Authors

    Published In

    Author List

  • Chen CLH; Bucy RP; Cooper MD
  • Start Page

  • 79
  • End Page

  • 86
  • Volume

  • 2
  • Issue

  • 1